Liposomal Tetrahydrocurcumin (Liposomal 4HC)

Liposomal Tetrahydrocurcumin (Liposomal 4HC) combines tetrahydrocurcumin-a hydrogenated metabolite of curcumin-with a high-purity phospholipid delivery system. Developed specifically for nutraceutical manufacturers, brand owners, and formulation developers, Liposomal 4HC resolves traditional curcumin processing challenges while providing a highly versatile delivery format for advanced nutritional products.

Key Formulation Advantages

Superior Water Dispersion: Conventional tetrahydrocurcumin is hydrophobic and difficult to disperse in water. Our phospholipid-based liposomal structure ensures uniform dispersion in aqueous systems, simplifying liquid and powder processing.

Light Appearance: Unlike bright yellow curcumin, which stains processing equipment and discolors products, Liposomal 4HC features an off-white appearance. This makes it ideal for light-colored capsules, clear drink mixes, and beauty-from-within applications.

Controlled Vesicle Structure: High-pressure homogenization ensures consistent particle size distribution and optimized active encapsulation for reliable stability.

Multi-Ingredient Synergy: Formulated to integrate seamlessly into complex matrixes targeting longevity, cellular health, and antioxidant support.

Ideal Synergy Partners

Longevity & Cellular Health: Alpha-Ketoglutarate (Ca-AKG), NMN, Resveratrol, Pterostilbene

Mitochondrial & Antioxidant Support: CoQ10, PQQ, Ergothioneine, Reduced L-Glutathione

Essential Nutrients: Selected vitamins, minerals, and botanical extracts

Typical Product Specifications

Parameter	Specification Target	Test Method
Product Name	Liposomal Tetrahydrocurcumin Powder	--
Active Content	Tetrahydrocurcumin (10% - 20% customizable)	HPLC
Phospholipid Source	Non-GMO Sunflower / Soy Lecithin	HPLC
Appearance	Off-white to light yellow free-flowing powder	Visual
Particle Size (Reconstituted)	D90 < 200 nm	Dynamic Light Scattering (DLS)
Encapsulation Efficiency	>= 80%	HPLC
Loss on Drying	<= 5.0%	USP <731>
Heavy Metals	Lead <= 0.5 ppm, Arsenic <= 0.5 ppm, Cadmium <= 0.5 ppm, Mercury <= 0.1 ppm	ICP-MS
Microbiological Limits	Total Plate Count < 1,000 CFU/g; Yeast & Mold < 100 CFU/g; E. coli & Salmonella: Absent	USP / AOAC
Residual Solvents	Complies with USP / ICH Guidelines	GC-MS
Shelf Life	24 Months in original sealed packaging	Stability Testing
Storage Conditions	Store in a cool, dry place (< 25 deg C) away from moisture and light	--

Manufacturing Process

Raw Material Qualification: Identity, purity, and microbial screening of incoming materials.

Active Preparation: Controlled thermal integration of tetrahydrocurcumin into the lipid matrix.

Liposomal Encapsulation: High-shear lipid hydration forms structured phospholipid vesicles.

Homogenization: High-pressure processing reduces particle size to ensure uniformity and stability.

Gentle Drying: Low-temperature drying preserves active integrity while creating a free-flowing powder.

Quality Release: Final analytical testing for assay, encapsulation efficiency, and purity standards.

Quality Assurance & Regulatory Documentation

We provide complete regulatory support to accelerate your product development and compliance verification:

Batch-specific Certificate of Analysis (COA)
Technical Data Sheet (TDS) & Safety Data Sheet (SDS)
Particle Size & Encapsulation Efficiency Reports
Heavy Metal, Pesticide, and Residual Solvent Screening (ICH Compliance)
Allergen-Free, Non-GMO, Halal, Kosher, and cGMP Certifications

Target Applications

Dietary Supplements: Premium capsules, multipill systems, and wellness tablets.

Healthy Aging & Cellular Care: Longevity formulas paired with mitochondrial health actives.

Nutricosmetics: Light-colored skin-support beverages, sachets, and stick packs.

Functional Foods & Beverages: Ready-to-Mix (RTM) powders, liquid shots, and functional drink mixes.

Packaging & Supply Options

Standard Packaging: 1 kg aluminum foil bags | 10 kg food-grade cartons | 25 kg fiber drums

Bulk Capabilities: Custom active load percentages, particle sizes, and carrier selection available upon request.

FAQ

Q: What is Liposomal Tetrahydrocurcumin?

A: Liposomal Tetrahydrocurcumin is tetrahydrocurcumin incorporated into a phospholipid-based liposomal delivery system. It is developed for nutritional and nutraceutical formulations that require an advanced delivery format.

Q: What is the difference between Tetrahydrocurcumin and Curcumin?

A: Tetrahydrocurcumin is a hydrogenated metabolite of curcumin. One important formulation difference is appearance: tetrahydrocurcumin is much lighter in color than conventional curcumin.

Q: What is the difference between Liposomal 4HC and conventional 4HC?

A: Both contain tetrahydrocurcumin as the active ingredient. The main difference is the delivery format. Conventional 4HC is supplied in a standard ingredient form, while Liposomal 4HC uses a phospholipid-based liposomal system.

Q: Is Liposomal Tetrahydrocurcumin water soluble?

A: Liposomal technology is intended to improve dispersion in suitable aqueous systems. However, dispersion should not automatically be described as complete water solubility. Actual performance depends on the formulation and should be confirmed through application testing.

Q: What phospholipid is used in the liposomal system?

A: The phospholipid source and specification depend on the actual product formulation. The specific phospholipid should be confirmed in the current product specification or technical data sheet.

Q: What quality documents are available for bulk purchasing?

A: Depending on customer requirements and the actual product specification, documents may include COA, specification sheet, TDS, SDS, microbiological reports, heavy metal reports, allergen statements, and other applicable documentation.

Q: Can Liposomal 4HC be used in functional beverages?

A: It can be evaluated for selected beverage applications where its dispersion characteristics are compatible with the formulation. Factors such as pH, processing temperature, dosage, excipients, packaging, and shelf-life requirements should be evaluated during product development.

Q: Can the product specification or packaging be customized?

A: Customization can be discussed according to the application, required specification, order volume, packaging format, and regulatory requirements of the target market. Final options should be confirmed before commercial production.

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