Liposomal 5-Aminolevulinic Acid (Liposomal 5-ALA)

Liposomal 5-Aminolevulinic Acid (Liposomal 5-ALA) combines 5-aminolevulinic acid with an advanced liposomal delivery system. It is designed for formulation developers and procurement teams seeking a lipid-based delivery format rather than conventional free-form 5-ALA.

Product Specifications

Parameter	Specification
Product Name	Liposomal 5-Aminolevulinic Acid
Abbreviation	Liposomal 5-ALA
Active Ingredient	5-Aminolevulinic Acid
CAS No.	106-60-5 (Free acid) / 5451-09-2 (HCl salt)
Appearance	Pale yellow to light brown liquid / suspension
5-ALA Content	5.0% – 10.0% (Customizable based on product grade)
Particle Size (D50)	100 – 200 nm
PDI (Polydispersity Index)	< 0.25
Encapsulation Efficiency	≥ 85%
pH Range	4.5 – 6.5
Lipid Composition	Hydrogenated Phosphatidylcholine (HPC), Cholesterol
Dispersion Characteristics	Readily dispersible in aqueous media
Microbiological Control	Total Plate Count < 1,000 CFU/g; Yeast & Mold < 100 CFU/g; Pathogens: Negative
Storage Condition	Store at 2 – 8°C, protected from light and moisture
Shelf Life	12 to 24 months in original unopened packaging
Packaging Options	1 kg, 5 kg, 25 kg food/cosmetic-grade drums
MOQ	1 kg (Sample/Trial), 25 kg (Commercial Supply)

Key Technical Parameters

5-ALA Content: Standardized active content (5.0% – 10.0%) verified via HPLC analytical methods for each batch.

Particle Size (100–200 nm): Measured via Dynamic Light Scattering (DLS) to ensure consistent physical delivery characteristics.

PDI (< 0.25): Low polydispersity index indicates a uniform, monodisperse particle size distribution across batches.

Encapsulation Efficiency (≥ 85%): High entrapment rate ensures the majority of 5-ALA remains encapsulated within the lipid bilayer.

Lipid Composition: High-purity lipid matrix (Phosphatidylcholine and Lecithin) clearly defined to ensure formula compatibility.

Quality Control & Process Control

Each commercial production batch undergoes strict process and quality control, covering:

High-pressure homogenization and temperature-controlled processing

Active-to-lipid ratio verification

Active assay (HPLC), particle size, PDI, and encapsulation testing

Heavy metals, elemental impurities, and microbiological testing

Low-microbial handling and protective light-blocking packaging

Every shipment includes a batch-specific Certificate of Analysis (COA). Independent third-party testing can be arranged prior to production upon request.

Application Areas & Regulatory Notice

Nutraceuticals & Supplements: Suitable for liquid supplements and advanced functional nutrition concepts.

Functional Nutrition: Ideal for cellular and metabolic health product formulations.

Cosmetics: Applicable for advanced topical skincare delivery systems where regulatory approval permits.

R&D Projects: Ideal for comparative stability, particle size, and encapsulation efficiency studies.

Regulatory Notice: The regulatory status of 5-ALA varies globally across food, cosmetic, and pharmaceutical categories. Buyers must verify local regulatory compliance for their specific end-use application.

Technical Documentation Package

We support supplier qualification by providing a complete documentation set upon request:

Product Specification & Technical Data Sheet (TDS)
Batch-specific Certificate of Analysis (COA)
Safety Data Sheet (SDS / MSDS)
Stability Summary Data
Allergen, Non-GMO, and BSE/TSE Declarations
Heavy Metal & Microbiological Compliance Statements
Country of Origin Certificate

Buyer Qualification Checklist

Evaluation Point	What to Confirm
Active Identity & Assay	Confirmed CAS and defined 5-ALA content (5.0% – 10.0%)
Liposomal Quality	Particle size (100–200 nm), PDI (< 0.25), Encapsulation (≥ 85%)
Lipid System	Transparent lipid source and composition details
Stability & Storage	Verified shelf life under 2 – 8°C storage conditions
Documentation	COA, SDS, TDS, and regulatory declarations provided
Commercial Terms	Flexible sample availability (1 kg MOQ) and scalable bulk supply

FAQ

Q: What is Liposomal 5-ALA?

A: Liposomal 5-ALA is 5-aminolevulinic acid incorporated into a liposomal delivery system. It is intended for product developers evaluating a lipid-based delivery format instead of conventional free-form 5-ALA.

Q: What is the difference between Liposomal 5-ALA and regular 5-ALA?

A: Regular 5-ALA refers to the active ingredient supplied in a defined chemical form. Liposomal 5-ALA combines 5-ALA with a liposomal carrier system. Therefore, buyers need to evaluate both the active ingredient and additional liposomal parameters.

Q: Which specifications are important when purchasing Liposomal 5-ALA?

A: Important specifications may include 5-ALA content, particle size, PDI, encapsulation efficiency, lipid composition, pH, appearance, microbiological quality, stability, and storage conditions.

Q: Can I request a COA for Liposomal 5-ALA?

A: Yes. A batch-specific COA can be provided according to the agreed product specification. Additional testing requirements can be discussed for projects that require independent verification.

Q: What technical documents are available?

A: Depending on the product grade and intended application, documents may include the product specification, COA, SDS/MSDS, technical data sheet, stability information, analytical information, and relevant quality or regulatory statements.

Q: Is Liposomal 5-ALA suitable for nutraceutical formulations?

A: It can be evaluated for nutraceutical and functional-nutrition development. Final suitability depends on the finished product, dosage form, formulation conditions, target market, and applicable regulations.

Q: Can Liposomal 5-ALA be supplied in bulk?

A: Yes. Commercial supply can be discussed according to the required specification, order volume, packaging format, and production schedule. MOQ and lead time should be confirmed for each project.

Q: How should Liposomal 5-ALA be stored?

A: Storage conditions should follow the product-specific specification and stability data. Temperature, light exposure, transportation conditions, and temperature fluctuations should be controlled according to the validated requirements for the product.

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Liposomal 5-Aminolevulinic Acid (Liposomal 5-ALA)