Liposomal Beta-Hydroxybutyrate (Liposomal BHB)

Liposomal Beta-Hydroxybutyrate (Liposomal BHB) combines high-purity beta-hydroxybutyrate with an advanced phospholipid-based liposomal delivery system.

Engineered specifically for B2B ingredient buyers, R&D formulators, and contract manufacturers (CDMOs), this ingredient provides a mineral-managed, highly stable, and bioavailable alternative to traditional BHB salts for dietary supplements, sports nutrition, and functional beverages.

Technical Specifications & Quality Benchmarks

Parameter	Specification Benchmark	Test Method / Equipment
Product Name	Liposomal Beta-Hydroxybutyrate	--
Isomer Profile	Enantiomer-Pure R-BHB (D-BHB) or Mixed DL-BHB	HPLC
Active BHB Content	30% - 50% (Powder Grade); Custom liquid concentrates available	HPLC
Phospholipid Source	Non-GMO Sunflower / Soy Lecithin (PC >= 20%)	HPLC / TLC
Particle Size (D90)	< 200 nm	Dynamic Light Scattering (DLS)
Polydispersity Index (PDI)	< 0.25 (Uniform particle distribution)	Dynamic Light Scattering (DLS)
Encapsulation Efficiency	>= 85%	Ultrafiltration + HPLC
Appearance	Fine, free-flowing, off-white to light yellow powder (or liquid dispersion)	Visual
Moisture Content	<= 5.0%	Karl Fischer / Loss on Drying
pH Stability Window	pH 3.5 - 7.2	pH Meter
Total Heavy Metals	<= 10 ppm	ICP-MS
Lead (Pb)	<= 1.0 ppm	ICP-MS
Arsenic (As)	<= 1.0 ppm	ICP-MS
Cadmium (Cd)	<= 0.5 ppm	ICP-MS
Mercury (Hg)	<= 0.1 ppm	ICP-MS
Total Plate Count	< 1,000 CFU/g	USP / AOAC
Yeast & Mold	< 100 CFU/g	USP / AOAC
Pathogens (E. coli / Salmonella)	Negative / 25g	USP / AOAC

Formulation & R&D Guidelines

PH Stability Window: Liposomal BHB is engineered to maintain structural integrity between pH 3.5 and 7.2. Ideal for acidic functional beverages, ready-to-drink (RTD) shots, and neutral powder mixes.

Shear and Temperature Sensitivity: High-shear mixing or high-temperature processing (> 75 deg C) may alter liposomal morphology. Low-temperature addition post-homogenization is recommended for liquid lines.

Excipient Compatibility: Avoid high concentrations of strong ionic surfactants or unbuffered organic solvents that may disrupt the lipid membrane.

Target Applications

Sports & Performance Nutrition: Pre-workout powders, intra-workout hydration matrices, endurance gels, and energy shots.

Functional Beverages & RTDs: Ready-to-drink ketone beverages, functional wellness shots, and liquid dietary supplements.

Ketogenic & Metabolic Health: Clean-label keto supplements, fasting support formulas, and cognitive performance blends.

Dietary Supplements: Hard capsules, stick packs, sachets, and multi-active wellness powders.

Commercial & Supply Chain Information

Manufacturing Standards: Produced in cGMP-certified, ISO 22000, HACCP, Halal, and Kosher compliant facilities.

Minimum Order Quantity (MOQ): Standard stock items: 25 kg (Fibre drum with inner double PE bags); Custom formulations: 100 kg - 500 kg.

Standard Packaging: 25 kg/drum; Aluminum foil vacuum pouches available for sample or pilot quantities.

Shelf Life & Storage: 24 months from manufacturing date when stored unopened in a cool, dry place (< 25 deg C), protected from direct sunlight and heat.

Lead Time: Standard Stock Grades: 3 - 5 Business Days dispatch; Custom Formulations: 2 - 3 Weeks.

Global Regulatory & Quality Compliance Package

To ensure smooth customs clearance and regulatory approval for international buyers, every commercial order includes:

Batch-Specific Certificate of Analysis (COA)
Safety Data Sheet (SDS) / MSDS
Particle Size Distribution Report (DLS Chart)
Non-GMO, Allergen-Free, and BSE/TSE-Free Declarations
Method of Analysis (MOA) and Stability Summary Report

FAQ

Q: What is Liposomal Beta-Hydroxybutyrate?

A: Liposomal Beta-Hydroxybutyrate is a BHB ingredient formulated with a phospholipid-based liposomal delivery system. It is intended for applications including sports nutrition, dietary supplements, functional beverages and ketogenic nutrition products.

Q: How is Liposomal BHB different from conventional BHB salts?

A: Conventional BHB ingredients are commonly supplied as mineral salts such as sodium BHB, calcium BHB, magnesium BHB or potassium BHB. Liposomal BHB uses a phospholipid-based delivery system, so the two formats have different composition and formulation characteristics.

Q: What specifications should I request for Liposomal BHB?

A: Important specifications may include BHB content, BHB form or isomer profile, phospholipid composition, particle size, PDI, loading or encapsulation data, microbiological limits, heavy metals, moisture, stability, shelf life and storage conditions.

Q: Can Liposomal BHB be used in functional beverages?

A: It can be evaluated for functional beverages, but compatibility testing is recommended. Particle size, PDI, pH, dispersion, processing conditions and finished-product stability should be evaluated before commercial production.

Q: Can Liposomal BHB replace sodium BHB?

A: Liposomal BHB should not be treated as a direct one-to-one replacement without formulation testing. Sodium BHB and Liposomal BHB have different compositions and delivery formats, so dosage, mineral contribution, processing behavior and stability should be evaluated separately.

Q: Can Liposomal BHB be supplied as a powder?

A: The available physical form depends on the specific product grade and manufacturing process. Buyers requiring a powder should confirm BHB concentration, carrier composition, reconstitution behavior, stability and storage requirements.

Q: Can Liposomal BHB be customized?

A: Potential customization may include BHB concentration, BHB form, phospholipid system, particle-size target, PDI, loading or encapsulation performance, physical format and packaging. The final specification depends on the intended application.

Q: What documents should I request before bulk procurement?

A: A typical technical package may include a product specification, batch-specific COA and SDS, together with applicable microbiological, heavy-metal, stability, allergen, Non-GMO, origin and packaging documentation.

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