Pyrroloquinoline Quinone (PQQ) Powder

Pyrroloquinoline Quinone (PQQ) is a premium redox-active quinone ingredient widely utilized in dietary supplements, cellular energy formulations, and fortified functional beverages.

Technical Specifications at a Glance

Parameter	Quality Requirement / Standard	Testing Method Reference
Product Name	Pyrroloquinoline Quinone Disodium Salt	In-house / USP Standard
CAS Number	122628-50-6	N/A
Appearance	Reddish-brown to dark brown powder	Visual
Assay (HPLC)	>= 98.0% (Calculated on dried basis)	HPLC (Validated method)
Identification	Positive by HPLC / IR Spectroscopy	HPLC / FT-IR
Moisture / Water Content	Controlled within specification limit	Karl Fischer / Loss on Drying
Heavy Metals (Total)	<= 10 ppm	ICP-MS / AAS
Lead (Pb)	<= 0.5 ppm	ICP-MS
Arsenic (As)	<= 0.5 ppm	ICP-MS
Cadmium (Cd)	<= 0.5 ppm	ICP-MS
Mercury (Hg)	<= 0.1 ppm	ICP-MS
Total Aerobic Count	<= 1,000 CFU/g	USP <2021> / EP
Yeast & Mold	<= 100 CFU/g	USP <2021> / EP
E. coli & Salmonella	Absent in 10g / 25g	USP <2022> / EP
Residual Solvents	Meets USP <467> / ICH guidelines	GC-HS

PQQ Assay and Identity Verification

HPLC Assay & Peak Integrity: We utilize validated High-Performance Liquid Chromatography (HPLC) to evaluate PQQ purity. Procurement teams receive complete batch documentation, including analytical methods, reference standard specifications, and chromatograms upon request.

Identity Testing: Identity is confirmed via HPLC retention time alignment against an authentic reference standard alongside FT-IR spectrophotometry, ensuring material integrity prior to release.

Rigorous Batch Release: Every commercial batch undergoes full testing against approved specifications. Our batch-release protocol guarantees consistent bulk density, particle size distribution, and solubility characteristics across shipments.

Supplier Qualification Documentation Checklist

Document Type	Purpose / Audience	Included Information
Product Specification Sheet	R&D / Procurement	Chemical limits, physical properties, standard test methods
Batch COA	QC / Receiving	Actual test values for the specific shipment lot
Technical Data Sheet (TDS)	Formulators	Solubility, stability profile, processing guidelines
Safety Data Sheet (SDS)	EHS / Warehouse	Hazard identification, handling, emergency procedures
Contaminant Reports	QA / Compliance	Full third-party ICP-MS heavy metals & residual solvents data
Regulatory Statements	Regulatory Affairs	Allergen, Non-GMO, BSE/TSE, Halal/Kosher status

Commercial Applications & Regulatory Considerations

Dietary Supplements & Nootropic Formulations
PQQ is widely integrated into formulations focused on cellular energy metabolism, mitochondrial function, and cognitive health.

Formats: Hard Capsules, Tablets, Powder Sticks, Sachets, Softgels.

Synergistic Blends: Commonly formulated alongside Coenzyme Q10, Alpha-GPC, NMN, or Acetyl-L-Carnitine.

Functional Beverages & Energy Shots
PQQ Disodium Salt exhibits good water solubility, making it ideal for fortified beverages, electrolyte mixes, and ready-to-drink (RTD) concepts.

Regulatory Compliance: PQQ disodium salt has been evaluated under US FDA GRAS (Generally Recognized As Safe) notices for specified beverage categories at defined intake levels.

Regulatory Compliance Note: Scientific literature regarding cellular energy or mitochondrial health should not be converted directly into disease-treatment claims on consumer packaging. Finished-product labeling must comply with local regulations (e.g., FDA, EFSA, SAMR).

Packaging, Storage, and Shelf-Life

Standard Bulk Packaging: 1 kg / aluminum foil bag, 5 kg / drum, or 25 kg / fiber drum with double PE inner liners.

Storage Requirements: Keep tightly sealed in a cool, dry place (<= 25 degrees C). Protect from direct sunlight, moisture, and ambient oxidation.

Shelf Life: 24 months from the manufacturing date when stored in unopened original packaging according to instructions.

FAQ

Q: What is the difference between PQQ Free Acid and PQQ Disodium Salt?

A: PQQ Disodium Salt is the stable, water-soluble commercial form most commonly used in global dietary supplements and beverages. Commercial specifications and dosages are generally calibrated to the disodium salt form.

Q: How do you verify residual solvents in PQQ raw material?

A: Residual solvents are analyzed using Headspace Gas Chromatography (GC-HS) in compliance with USP ICH guidelines to ensure no class 1 or unsafe class 2 solvents remain above permitted thresholds.

Q: Can I request a working sample and batch-specific COA before bulk ordering?

A: Yes. We supply evaluation samples along with the corresponding batch Certificate of Analysis, allowing your internal QA or third-party laboratory to verify specification compliance prior to commercial commitment.

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